In a commanding performance, the San Francisco 49ers topped the Arizona Cardinals 45-22 in Week 3 of the 2026 season. With this victory, the 49ers solidify their position as a formidable contender in the league, showcasing their offensive prowess and defensive strength. Brock Purdy led the charge for San Francisco, throwing for 295 yards and four touchdowns, demonstrating his ability to connect with key targets. Mike Evans had a standout game as well, racking up 123 receiving yards, while the Cardinals' Jeremiyah Love kept his team competitive with a strong ground game, totaling 123 rushing yards. However, it was Purdy's precision and efficiency that ultimately guided the 49ers to victory. Defensively, the 49ers were relentless, with Nick Bosa wreaking havoc on the Cardinals' offensive line, recording 2.5 sacks to disrupt their rhythm. Dre Greenlaw’s interception proved to be a turning point, halting a potential scoring drive by Arizona and shifting momentum firmly in favor of San Francisco. The combination of a potent offense and a staunch defense left the Cardinals struggling to keep pace throughout the game.