In a dominant performance, the San Francisco 49ers topped the Arizona Cardinals 56-28 in Week 3 of the 2026 season. With both teams vying for early-season momentum, the 49ers showcased their offensive firepower, solidifying their position as contenders in the NFC. Brock Purdy led the charge for San Francisco, throwing for an impressive 407 yards and six touchdowns, while Christian McCaffrey added to the offensive onslaught with 122 rushing yards. George Kittle was also a standout, racking up 166 receiving yards, proving to be a reliable target throughout the game. The 49ers' offense operated with precision, overwhelming the Cardinals' defense. Defensively, San Francisco made key plays that shifted the momentum in their favor. DeForest Buckner was a force up front, registering two sacks that disrupted Arizona's rhythm, while Deommodore Lenoir's interception helped halt any potential scoring drives by the Cardinals. The turning point came in the second quarter, when the 49ers scored three touchdowns in quick succession, effectively sealing the game before halftime.