In a decisive Week 12 matchup, the Arizona Cardinals triumphed over the Indianapolis Colts with a final score of 38-21, solidifying their position in the playoff race. The Cardinals showcased their offensive prowess, aiming to maintain momentum as the season approaches its climax. Quarterback Ty Simpson led the charge for Arizona, throwing for 293 yards and three touchdowns, effectively orchestrating the Cardinals' high-powered offense. Rashee Rice emerged as his top target, racking up 110 receiving yards, while the Colts' Jonathan Taylor kept the game competitive with a solid 94 rushing yards, but ultimately, it wasn't enough to keep pace with Arizona's offensive onslaught. Defensively, the Cardinals made their presence felt, led by Foyesade Oluokun's ten total tackles and a key sack from Kaleb Proctor. The turning point came in the second quarter when Arizona's defense stifled a Colts drive, allowing the Cardinals to capitalize and extend their lead, which proved insurmountable for Indianapolis as the game progressed.