In a decisive Week 3 matchup, the San Francisco 49ers topped the Arizona Cardinals with a commanding 34-14 victory. With both teams looking to establish momentum early in the 2026 season, the 49ers demonstrated their dominance on both sides of the ball, solidifying their position as a contender in the league. Brock Purdy was the standout performer for San Francisco, throwing for 283 yards and three touchdowns, showcasing his ability to lead the offense effectively. Mike Evans proved to be his favorite target, racking up an impressive 163 receiving yards, while Christian McCaffrey added a solid ground game with 68 rushing yards. Together, they propelled the 49ers to a commanding offensive performance. Defensively, the 49ers were relentless, with Nick Bosa recording three sacks to keep the Cardinals' offense under constant pressure. Upton Stout led the team with nine total tackles, ensuring key stops throughout the game. The turning point came when Dre Greenlaw intercepted a pass in the second quarter, shifting momentum firmly in San Francisco's favor and allowing them to build an insurmountable lead.