In a tightly contested battle, the Indianapolis Colts narrowly defeated the Buffalo Bills 14-10 in Week 2 of the 2027 season. Both teams were looking to build momentum early in the year, but it was the Colts who emerged victorious in this hard-fought matchup. Josh Allen led the Bills with 212 passing yards, but it was Jordan Mitchell's ground game that made the difference for Indianapolis, as he rushed for 59 yards, helping to keep the chains moving. Keon Coleman was a notable target for Allen, recording 64 receiving yards, but the Colts' offense managed to capitalize on key moments to secure the win. Defensively, the Colts made their mark with Brandon Jones leading the way with 11 total tackles, while Laiatu Latu was a force up front, recording 2.5 sacks that disrupted the Bills' offensive rhythm. The game's turning point came late in the fourth quarter when Latu's pressure forced an errant throw from Allen, allowing the Colts to maintain their slim lead and ultimately seal the victory.