In a thrilling Week 5 showdown, the San Francisco 49ers narrowly defeated the Seattle Seahawks with a final score of 26-22. Both teams were looking to solidify their playoff aspirations, making this matchup crucial in the competitive landscape of the 2026 season. Derrick Henry was the star of the night for the 49ers, rushing for an impressive 173 yards, showcasing his power and agility on multiple key plays. Quarterback Joe Flacco contributed with a steady performance, throwing for one touchdown that helped maintain momentum for San Francisco. On the Seahawks side, Fernando Mendoza led the passing attack with 210 yards, but struggled to find the end zone amid the defensive pressure. Defensively, Vita Vea was a game-changer for the 49ers, recording 5 total tackles and a staggering 3.5 sacks that disrupted Seattle's offensive rhythm. The turning point came late in the fourth quarter when Vea's relentless pressure forced a crucial turnover, allowing San Francisco to maintain their lead and secure the victory. Tyson Campbell’s interception also played a significant role, helping to stifle any late-game comeback efforts from the Seahawks.