In a dominating performance, the San Francisco 49ers topped the Arizona Cardinals 43-14 in Week 3 of the 2026 season. With this win, the 49ers solidified their standing as a team to watch, showcasing their offensive firepower and defensive prowess against a struggling Cardinals squad. Brock Purdy led the charge for San Francisco, throwing for 262 yards and three touchdowns, demonstrating his ability to command the field with precision. Meanwhile, Christian McCaffrey was a force on the ground, racking up 120 rushing yards and keeping the Arizona defense on its heels. Mike Evans also made his mark with an impressive 97 receiving yards, contributing significantly to the 49ers' scoring. Defensively, San Francisco was relentless, with Fred Warner leading the team with six total tackles, ensuring that the Cardinals struggled to find any rhythm. The turning point came in the second quarter when the 49ers' defense stifled a potential scoring drive by Arizona, leading to a quick turnover that allowed San Francisco to extend their lead and ultimately secure the decisive victory.