In a tightly contested matchup, the Buffalo Bills narrowly defeated the Detroit Lions 22-16 in Week 2 of the 2026 season. Both teams were looking to establish momentum early in the season, but it was the Bills who emerged victorious, improving their record while the Lions fell short yet again. Josh Allen was a dual-threat for Buffalo, throwing for one touchdown and rushing for 62 yards, showcasing his versatility and playmaking ability. Jared Goff led the Lions with 241 passing yards, but it was Amon-Ra St. Brown who shone brightly in the receiving corps, racking up 110 yards. Despite strong offensive performances from both sides, it was the Bills who capitalized on their opportunities. Defensively, the game turned when Ed Oliver recorded 1.5 sacks, disrupting Goff's rhythm and applying consistent pressure throughout the contest. The Bills’ defense made key stops at crucial moments, which ultimately sealed the victory for Buffalo. Ennis Rakestraw Jr. led the Lions' defense with seven tackles, but it wasn’t enough to overcome the Bills' timely defensive plays.