The Denver Broncos topped the San Francisco 49ers 25-10 in a decisive Week 4 matchup of the 2026 season. With both teams looking to build momentum, the Broncos emerged victorious, showcasing a well-rounded performance that solidified their standing in the league. Bo Nix led the charge for Denver, throwing for 167 yards, while RJ Harvey contributed on the ground with 46 rushing yards. Jaylen Waddle was a standout in the receiving game, racking up 86 yards to support the Broncos' offensive efforts. Christian McCaffrey of the 49ers managed to find the end zone with a passing touchdown, but it wasn’t enough to keep pace with Denver’s balanced attack. Defensively, the Broncos made their mark with an impressive performance, highlighted by Channing Tindall’s two interceptions that shifted the momentum in Denver's favor. Paulson Adebo's three total tackles were crucial in limiting San Francisco’s offensive production, while Gracen Halton's sack for the 49ers proved to be a lone bright spot in a challenging evening. The turning point came when Tindall’s first interception led to a quick touchdown, putting the Broncos firmly in control and setting the tone for the remainder of the game.