In a dominant performance, the San Francisco 49ers topped the Arizona Cardinals 41-10 in Week 3 of the 2026 season. This victory not only showcased their offensive prowess but also solidified their position as a formidable contender in the league early in the season. Brock Purdy was the star of the show for the 49ers, throwing for four touchdowns and orchestrating a potent aerial attack. Meanwhile, Christian McCaffrey contributed significantly on the ground with 99 rushing yards, while Mike Evans made his mark through the air with an impressive 138 receiving yards. Jacoby Brissett, despite the loss, put up impressive numbers for the Cardinals, leading the team with 285 passing yards. Defensively, the 49ers were relentless, with Nick Bosa leading the charge with 1.5 sacks, putting pressure on Brissett throughout the game. Dre Greenlaw's interception proved to be a critical turning point, halting any momentum the Cardinals were building and allowing San Francisco to extend their lead. With a strong showing on both sides of the ball, the 49ers clearly established themselves as a force to be reckoned with this season.