In a decisive Week 4 matchup, the Denver Broncos dominated the San Francisco 49ers with a final score of 45-14, solidifying their position in the early stages of the 2026 season. With playoff aspirations on the line, the Broncos showcased their offensive firepower and defensive tenacity, leaving the 49ers in their wake. Jonah Coleman was the standout performer for Denver, racking up 117 rushing yards and contributing significantly to the Broncos' prolific ground game. Quarterback Brock Purdy led the 49ers through the air, throwing for 246 yards and two touchdowns, but the 49ers' offense struggled to keep pace with the relentless Broncos. Mike Evans also had a solid showing for San Francisco, accumulating 71 receiving yards, but it was not enough to spark a comeback. Defensively, Nik Bonitto made an impact for the Broncos with two sacks, helping to apply consistent pressure on the 49ers' quarterback. While Fred Warner recorded an impressive 11 tackles and an interception for San Francisco, the turning point came in the second quarter when the Broncos scored three touchdowns in quick succession, effectively putting the game out of reach. The Broncos' defense held strong throughout, limiting the 49ers' ability to respond and sealing the victory with their relentless performance.