In a thrilling Week 1 matchup of the 2026 season, the Los Angeles Chargers topped the Arizona Cardinals with a final score of 35-21. This game marked a strong start for the Chargers as they showcased their offensive prowess against a competitive Cardinals squad looking to make an impact this season. Justin Herbert led the charge for Los Angeles, throwing for three touchdown passes while demonstrating his ability to connect with his receivers. Meanwhile, Omarion Hampton was a force on the ground, racking up an impressive 193 rushing yards, keeping the Cardinals' defense on its heels. For Arizona, Mitchell Trubisky put up solid numbers with 263 passing yards and found Marvin Harrison Jr. for 82 receiving yards, but it wasn't enough to mount a comeback. Defensively, the Chargers made key plays that shifted the momentum in their favor, highlighted by Cam Hart’s two interceptions that stifled the Cardinals' offensive drives. Tuli Tuipulotu's lone sack added pressure on Trubisky, further hindering Arizona's ability to score. The turning point came in the second quarter when the Chargers capitalized on a turnover, quickly extending their lead and establishing control of the game.