The San Francisco 49ers dominated the Washington Commanders with a final score of 49-7, solidifying their position in the standings during Week 6 of the 2026 season. This decisive victory showcased the 49ers' offensive firepower and defensive prowess, leaving the Commanders struggling to keep pace throughout the game. Brock Purdy was the standout for San Francisco, throwing for an impressive 378 yards and five touchdowns, demonstrating both precision and playmaking ability. His connection with George Kittle was particularly lethal, as Kittle racked up 114 receiving yards, making crucial catches that extended drives and led to scoring opportunities. Meanwhile, the Commanders' Breece Hall managed to find some success on the ground with 69 rushing yards, but it was not nearly enough to shift momentum. Defensively, the 49ers were equally effective, highlighted by Ephesians Prysock's key interception that turned the tide in the first half. The 49ers' defense consistently pressured the Commanders' offense, limiting their scoring chances and forcing three turnovers overall. The defining moment came when Prysock's interception set up another quick touchdown, pushing San Francisco's lead to an insurmountable margin and sealing the game well before the final whistle.