In a commanding display, the San Francisco 49ers topped the Arizona Cardinals 40-3, solidifying their dominance in the early part of the 2026 season. With this victory, the 49ers improved to an impressive record, while the Cardinals continue to seek answers in a struggling campaign. Brock Purdy was the star of the show, throwing for an impressive 374 yards and four touchdowns, showcasing his ability to connect with receivers in crucial moments. Ricky Pearsall was his go-to target, racking up 101 receiving yards, while Chase Brown added a solid ground game with 79 rushing yards to help keep the chains moving. Defensively, the 49ers were relentless, with Mykel Williams recording two sacks that put consistent pressure on the Cardinals' offense. Nate Hobbs made a significant impact with two interceptions, turning the tide firmly in favor of San Francisco. The turning point came early in the second quarter when Hobbs' second pick set up another touchdown drive, pushing the 49ers' lead to an insurmountable margin.