In a dominant performance, the Denver Broncos defeated the Buffalo Bills 42-7 in Week 16 of the 2027 season, solidifying their playoff positioning. The Broncos showcased their offensive firepower, leaving the Bills struggling to keep pace throughout the contest. Quarterback Bo Nix led the way for Denver, throwing for 222 yards and two touchdowns, while Jonah Coleman shined on the ground with a remarkable 135 rushing yards. Despite the loss, Darius Slayton put up a respectable 96 receiving yards for Buffalo, but it was clear that the Broncos' offense had the upper hand in this matchup. Defensively, the Broncos made a significant impact, highlighted by Nik Bonitto's three sacks and Patrick Surtain II's interception. The game turned decisively in the second quarter when the Broncos scored back-to-back touchdowns, effectively putting the game out of reach for Buffalo. With the defense consistently pressuring the Bills’ offense, Denver's comprehensive effort secured a commanding victory.