In an impressive display of offensive firepower, the San Francisco 49ers topped the Arizona Cardinals 48-21 in Week 3 of the 2026 season. This victory solidifies the 49ers' position as a formidable contender, showcasing their ability to dominate both on the ground and through the air. Brock Purdy led the charge for San Francisco, throwing for 349 yards and three touchdowns, proving to be a pivotal force in the team's success. Christian McCaffrey complemented Purdy's performance with a stellar 124 rushing yards, while Mike Evans emerged as a key target, racking up 121 receiving yards. Together, they formed a potent offensive trio that kept the Cardinals' defense on their heels throughout the game. Defensively, the 49ers also made their mark, with Upton Stout securing an interception that shifted the momentum in the second half. While Chidobe Awuzie of the Cardinals recorded a solid eight tackles, it was the 49ers' ability to force turnovers and pressure the quarterback that ultimately dictated the outcome. The game turned decisively in San Francisco's favor late in the second quarter, as Purdy connected with Evans for a touchdown, allowing the 49ers to pull away and maintain their lead.