In a dominating performance, the Philadelphia Eagles defeated the San Francisco 49ers 48-7 in Week 17 of the 2026 season, solidifying their playoff positioning with a decisive victory. The Eagles showcased their offensive prowess, leaving the 49ers struggling to keep pace throughout the game. Quarterback Jalen Hurts was the star of the show, throwing for an impressive 355 yards and four touchdowns. Saquon Barkley also shone, contributing significantly with 85 rushing yards and leading the receiving corps with 91 yards through the air. The Eagles' offense operated like a well-oiled machine, capitalizing on opportunities and converting drives into points with ease. Defensively, the Eagles proved relentless, with Cooper DeJean snagging two interceptions to stifle any hopes of a 49ers comeback. Jonathan Greenard added pressure with a sack, while Ji'Ayir Brown’s six tackles provided a solid effort for San Francisco, but it was clearly not enough. The turning point came early in the second half when DeJean's second interception set up another quick Eagles score, effectively putting the game out of reach for the 49ers.