The Denver Broncos dominated the San Francisco 49ers with a commanding 42-6 victory in Week 4 of the 2026 season. With this win, the Broncos continue to solidify their position as a formidable contender in the league, while the 49ers struggle to find their footing early in the season. Bo Nix was the standout performer for the Broncos, throwing for 282 yards and four touchdowns, showcasing his ability to lead the offense effectively. Courtland Sutton was his top target, racking up an impressive 136 receiving yards, contributing significantly to the Broncos' offensive explosion. Meanwhile, Christian McCaffrey led the 49ers on the ground, but his 72 rushing yards were nowhere near enough to keep pace with Denver's offensive firepower. Defensively, the Broncos were relentless, with Brandon Jones making a game-changing impact by securing two interceptions. Zach Allen added to the pressure on the 49ers' offense with a sack, while the overall defensive unit stifled any attempts by San Francisco to mount a comeback. The turning point came early in the second half, when Jones's second interception set up another quick touchdown drive, effectively sealing the game for Denver.