In a commanding performance, the Seattle Seahawks defeated the San Francisco 49ers 33-10 in Week 12 of the 2026 season. This matchup was crucial for both teams as they jockey for playoff positioning, and Seattle's victory solidifies their place in the hunt as the season winds down. Sam Darnold led the charge for the Seahawks with an impressive 374 passing yards and two touchdowns, showcasing his ability to stretch the field. Tory Horton emerged as his favorite target, racking up 133 receiving yards and consistently moving the chains. Meanwhile, the 49ers struggled offensively, with Christian McCaffrey managing just 65 rushing yards, unable to find any rhythm against Seattle's robust defense. Defensively, the Seahawks applied consistent pressure and stifled the 49ers' offensive attempts. The game turned in the second quarter when Seattle's defense forced key turnovers, allowing Darnold to capitalize with scoring drives that extended their lead. San Francisco's Malik Mustapha led the team in tackles with four, but it wasn't enough to shift the momentum back in their favor as Seattle cruised to victory.