In an impressive display of offensive firepower, the San Francisco 49ers topped the Denver Broncos 41-21 in Week 4 of the 2026 season. With both teams looking to solidify their standings, the 49ers surged ahead, showcasing their dominance in all phases of the game. Leading the charge for the Broncos was quarterback Bo Nix, who threw for 400 yards and two touchdowns, but it wasn't enough to overcome San Francisco's relentless attack. On the ground, Christian McCaffrey ran wild for the 49ers, racking up an astounding 266 rushing yards, while Jaylen Waddle was the standout receiver for Denver, notching 144 receiving yards. This offensive showcase kept fans on the edge of their seats throughout the contest. Defensively, the 49ers were a force to be reckoned with, particularly in the second half. Nick Bosa dominated the pass rush with three sacks, consistently pressuring Nix and forcing mistakes. The turning point came late in the third quarter when Renardo Green intercepted a pass, shifting the momentum firmly in favor of San Francisco and sealing the victory.