In a dominating performance, the Los Angeles Rams routed the Arizona Cardinals 49-7 in Week 6 of the 2026 season. With this victory, the Rams solidified their position at the top of the division, showcasing their offensive firepower against a struggling Cardinals squad. Joe Milton delivered a standout performance for the Rams, throwing for an impressive 432 yards and six touchdowns, a display that left the Cardinals' defense reeling. DeVonta Smith was his primary target, hauling in 95 receiving yards to help fuel the offensive onslaught, while the Cardinals' ground game was virtually nonexistent, with Chase Brown managing a mere two rushing yards. The Rams' defense was equally impactful, with Will Anderson Jr. leading the charge with two sacks, while Treydan Stukes secured two interceptions, further stifling any hopes of a Cardinals comeback. The game's turning point came early in the second quarter when Stukes intercepted a pass, setting the stage for the Rams to score and extend their lead to 28-0, effectively putting the game out of reach.