In a commanding performance, the Buffalo Bills defeated the Detroit Lions 46-18 in Week 2 of the 2026 season. With this victory, the Bills improve their record to 2-0, showcasing their offensive firepower and defensive prowess as they look to establish themselves as contenders early in the season. Malik Willis was the standout performer for Buffalo, throwing for 223 yards and three touchdowns, leading a potent aerial attack. Ashton Jeanty complemented the passing game with an impressive 176 rushing yards, while Tyreek Hill added a strong receiving presence with 100 yards through the air. Together, they formed a dynamic offensive trio that kept the Lions’ defense on their heels all game long. Defensively, the Bills were relentless, with Mack Wilson Sr. leading the charge with four total tackles. The turning point came in the second quarter when Christian Gonzalez snagged two interceptions, both pivotal in shifting momentum toward Buffalo. Chauncey Golston also contributed with a critical sack, further disrupting Detroit's rhythm and sealing the game for the Bills.