In a commanding performance, the Denver Broncos defeated the San Francisco 49ers 45-21 in Week 4 of the 2026 season. With this victory, the Broncos solidify their position in the playoff race, while the 49ers face critical questions as they look to bounce back in the coming weeks. Bo Nix led the Broncos' offensive charge, throwing for three touchdowns and showcasing his ability to find the end zone effectively. RJ Harvey added a strong ground game, rushing for 119 yards, while Jaylen Waddle was a reliable target in the passing game, racking up 84 receiving yards. The offensive cohesion and execution were evident, allowing Denver to pull away early and maintain control throughout the contest. Defensively, the Broncos were relentless, with Germaine Pratt contributing significantly with 2.5 sacks and Talanoa Hufanga making a game-changing impact with two interceptions. Alex Singleton anchored the defense with 10 total tackles, ensuring that the 49ers struggled to gain momentum. The turning point came in the second quarter when Hufanga's second interception set up a quick score, allowing the Broncos to extend their lead and put the game out of reach for San Francisco.