In a commanding performance, the Houston Texans topped the Tennessee Titans 49-21 in Week 5 of the 2026 season. The Texans entered this matchup looking to maintain their momentum, and they did just that by dominating on both sides of the ball. C.J. Stroud was the standout performer for Houston, throwing for an impressive 381 yards and five touchdowns, showcasing his elite playmaking ability. Dalevon Campbell also made significant contributions, racking up 133 receiving yards and proving to be a reliable target throughout the game. Despite their efforts, the Titans' offense struggled to keep pace, with Nick Singleton leading their ground attack with only 54 rushing yards. Defensively, the Texans were equally impressive, with Will Anderson Jr. leading the charge by recording 2.5 sacks, disrupting the Titans' offensive rhythm. The turning point came when Houston's Henry To'oTo'o intercepted a pass, shifting the momentum firmly in the Texans' favor and setting the stage for their high-scoring onslaught. The Titans' defense couldn't respond, ultimately sealing their fate in this lopsided affair.