The Denver Broncos secured a commanding 50-29 victory over the Buffalo Bills in Week 16 of the 2026 season, solidifying their playoff hopes with a dominant performance. With both teams fighting for postseason positioning, Denver’s explosive offense proved too much for Buffalo to handle. Leading the charge for the Broncos was quarterback Bo Nix, who threw for an impressive 375 yards and six touchdowns, showcasing his ability to deliver in critical moments. Tight end Evan Engram was his favorite target, racking up 159 receiving yards that kept the Bills' defense on its heels. Although Buffalo’s James Cook III had a strong outing with 112 rushing yards, it wasn’t enough to keep pace with Denver's offensive firepower. Defensively, the Broncos were opportunistic, with Riley Moss snagging an interception that shifted momentum in their favor. Zach Allen added pressure with a sack, contributing to a defensive effort that limited Buffalo’s scoring opportunities. The turning point came early in the second half when Nix connected with Engram for a long touchdown, effectively sealing the game for Denver and showcasing their offensive prowess.