In a thrilling Week 4 matchup, the San Francisco 49ers narrowly defeated the Denver Broncos with a final score of 28-21. The stakes were high as both teams sought to bolster their playoff hopes, but it was the 49ers who ultimately emerged victorious, maintaining their momentum in the 2026 season. Brock Purdy led the charge for San Francisco, throwing for an impressive 311 yards, while the Broncos' Bo Nix matched him with two touchdown passes, keeping the game competitive. Denver's offense showcased standout performances, particularly from Troy Franklin, who racked up 144 receiving yards, and RJ Harvey, who contributed with 82 rushing yards to complement the passing attack. Defensively, the 49ers made critical plays that swung the game in their favor. Fred Warner's seven total tackles anchored a solid defensive effort, while Dre Greenlaw's sack and Kenny Moore II's interception provided pivotal moments that stifled the Broncos' drives. The game’s turning point came late in the fourth quarter when Moore's pick set up a touchdown drive that ultimately sealed San Francisco's win.