The Buffalo Bills topped the New England Patriots in a commanding 66-31 victory in Week 13 of the 2026 season. With playoff positioning on the line, the Bills showcased their dominance, solidifying their status as a team to watch as the season approaches its conclusion. James Cook III had a standout performance on the ground, racking up an impressive 410 rushing yards, while Drake Maye of the Patriots kept pace in the air, throwing for 302 yards and two touchdowns. A.J. Brown was the go-to target for New England, finishing with 68 receiving yards, but it was clear that the Bills' offensive firepower was too much to overcome. Buffalo's defense played a pivotal role in the outcome, with Mike Jackson securing two interceptions that shifted momentum back to the Bills at critical junctures. Cole Bishop led the team with six tackles, while Greg Rousseau added a sack to pressure Maye throughout the game. The combination of a relentless offense and a opportunistic defense proved too formidable for the Patriots, marking a definitive statement by Buffalo as they head into the final stretch of the season.