In a dominating performance, the Denver Broncos defeated the San Francisco 49ers with a final score of 63-21, marking a decisive victory in Week 4 of the 2026 season. With this win, the Broncos solidify their position as a contender in the league, showcasing an explosive offense against a struggling 49ers squad. Leading the charge for Denver was quarterback Bo Nix, who threw for an impressive 476 yards and five touchdowns, marking a standout day for the young signal-caller. Jaylen Waddle was his top target, racking up 144 receiving yards, while RJ Harvey contributed on the ground with 60 rushing yards. The Broncos' offensive firepower proved too much for San Francisco to handle throughout the game. Defensively, the Broncos made their mark with standout performances, particularly from linebacker Nik Bonitto, who recorded two sacks, and Jahdae Barron, who snagged three interceptions, showcasing a relentless pass rush and opportunistic secondary. The turning point came early in the second half when Barron intercepted a pass, setting the tone for a second-half onslaught that the 49ers could not recover from. Overall, Denver’s defense played a critical role in securing this emphatic victory.