In a dominant display, the Los Angeles Rams crushed the San Francisco 49ers with a final score of 46-10 in their Week 1 matchup of the 2026 season. The Rams showcased their offensive firepower, setting the tone for the year ahead while the 49ers struggled to keep pace. Matthew Stafford led the charge for Los Angeles, throwing for 344 yards and securing two touchdown passes, while Tre Tucker added a strong ground game with 94 rushing yards. Terrance Ferguson was a standout receiver, racking up 102 yards, making key catches that extended drives and put points on the board. Defensively, the Rams were relentless, with Myles Garrett making a significant impact by recording 2.5 sacks, disrupting the 49ers' offensive rhythm. Nate Landman contributed with six total tackles, and the defense overall stifled San Francisco’s attempts to find a groove. The turning point came in the second quarter when a crucial interception by Ephesians Prysock led to a quick Rams touchdown, solidifying their commanding lead and leaving the 49ers reeling.