In a commanding performance, the San Francisco 49ers defeated the Kansas City Chiefs by a score of 46-13 in Week 16 of the 2026 season. With playoff implications on the line, the 49ers showcased their offensive firepower, solidifying their position as a formidable contender in the league. Brock Purdy led the charge for San Francisco, throwing for an impressive 356 yards and five touchdowns, demonstrating pinpoint accuracy and poise in the pocket. Meanwhile, Christian McCaffrey contributed on the ground with 85 rushing yards, while Mike Evans emerged as Purdy's favorite target, racking up 162 receiving yards. This dynamic trio was instrumental in the 49ers' offensive onslaught that overwhelmed the Chiefs. Defensively, the 49ers also made their presence felt, with Nick Bosa recording a sack and disrupting Kansas City's rhythm. The turning point came when Purdy connected with Evans for a long touchdown in the second quarter, which shifted momentum dramatically in favor of San Francisco. The Chiefs struggled to respond, with Drue Tranquill's seven tackles serving as a lone bright spot in an otherwise tough outing for Kansas City.