In a tightly contested matchup, the Buffalo Bills held off the Detroit Lions with a final score of 21-16 in Week 2 of the 2026 season. Both teams were hungry for a win, but it was the Bills who managed to secure the victory at home, raising their record early in the season. Tyler Shough of the Lions put on an impressive performance, throwing for 279 yards and two touchdowns, showcasing his ability to move the ball effectively. Meanwhile, the Bills' Jeremiyah Love led the ground game with 95 rushing yards, providing a crucial balance to their offense. Davante Adams also shined for Detroit, racking up 135 receiving yards, but it wasn't enough to propel his team past the finish line. Defensively, the Bills made key stops, with Nate Wiggins leading the way with seven total tackles, helping to contain the Lions' explosive offense. The turning point came in the fourth quarter when Jalen Thompson's timely interception thwarted a potential game-tying drive from Detroit. Despite Aaron Donald's notable performance with 1.5 sacks, the Lions couldn't capitalize on their defensive efforts, allowing the Bills to secure the hard-fought win.