In a dominant display of offensive firepower, the Buffalo Bills topped the Arizona Cardinals 68-21 in Week 16 of the 2028 season. With playoff positioning on the line, Buffalo delivered a statement victory, showcasing their high-octane offense and solidifying their status as a contender. Quarterback Jalen Milroe led the Bills with an impressive performance, tossing three touchdown passes while establishing a strong rhythm with his receivers. Saquon Barkley was a force on the ground, racking up an astonishing 278 rushing yards, while Brenen Thompson shone in the passing game with 169 receiving yards. The Bills' offensive line provided the protection needed to keep the chains moving and put points on the board. Defensively, the Bills were equally impressive, limiting the Cardinals to just 21 points while forcing key turnovers. The game turned decisively in Buffalo's favor when Nahshon Wright intercepted a pass, halting a potential scoring drive for Arizona and shifting momentum back to the Bills. With Dadrion Taylor-Demerson leading the team with five tackles, Buffalo's defense consistently stifled the Cardinals, allowing the offense to build an insurmountable lead.