In a tightly contested matchup, the San Francisco 49ers secured a 27-18 victory over the Denver Broncos in Week 4 of the 2026 season. Both teams were looking to solidify their positions early in the year, but it was San Francisco that came out on top, demonstrating resilience and scoring efficiency. Jared Goff led the 49ers' offense with two touchdown passes, effectively capitalizing on the opportunities presented by Denver's defense. Meanwhile, James Cook III showcased his explosive running ability, racking up an impressive 154 rushing yards to keep the chains moving. On the other side, Jalen Hurts threw for 222 yards and kept the Broncos competitive, but it wasn't enough to overcome the 49ers' offensive firepower. Defensively, the 49ers made key plays at crucial moments, highlighted by Tuli Tuipulotu's two sacks that disrupted the Broncos' offensive rhythm. Nate Landman's interception also proved to be a pivotal moment, swinging momentum back in favor of San Francisco. Ultimately, the 49ers' defense held strong when it mattered most, allowing them to maintain control and secure the win.