In a commanding performance, the Detroit Lions topped the Buffalo Bills 42-21 in Week 2 of the 2026 season, solidifying their early-season momentum. The Lions showcased their offensive prowess, while the Bills struggled to keep pace, ultimately falling short in their home opener. Detroit's offense was led by a standout performance from Jeff Caldwell, who torched the Bills' secondary for 162 receiving yards, contributing significantly to their scoring onslaught. Quinshon Judkins added a solid ground game with 85 rushing yards, helping to maintain the Lions' offensive balance. Though Tua Tagovailoa shone for Buffalo with 282 passing yards and three touchdowns, it wasn't enough to keep up with Detroit's relentless attack. Defensively, the Lions made their mark with VJ Payne’s remarkable three interceptions, which proved pivotal in shifting the game's momentum. Will Anderson Jr. also contributed with a sack, disrupting Buffalo’s offensive rhythm. The turning point came when Payne's third interception set up a quick touchdown for Detroit, effectively sealing the win and demonstrating the Lions' dominance on both sides of the ball.