The Miami Dolphins secured a hard-fought 21-15 victory over the San Francisco 49ers in Week 2 of the 2026 season, marking an important early win for both teams as they vie for playoff positioning. The Dolphins' balanced offensive performance proved crucial in this tightly contested matchup. Brock Purdy led the 49ers with an impressive 266 passing yards and two touchdowns, showcasing his ability to stretch the field. However, it was Caleb Douglas of the Dolphins who shone brightest, racking up 99 receiving yards and providing a key target for Miami's passing game. The offensive battle was intense, but Miami's ability to convert crucial plays ultimately made the difference. Defensively, the Dolphins were formidable, with Zach Sieler dominating the 49ers' offensive line, registering 2.5 sacks. Darrell Baker Jr. also contributed significantly with seven total tackles, while JuJu Brents sealed the game with a critical interception. The turning point came late in the fourth quarter when Brents picked off Purdy, allowing Miami to maintain their lead and secure the victory.