In a high-scoring showdown, the Arizona Cardinals topped the Detroit Lions 54-38 in Week 5 of the 2026 season. With both teams looking to establish themselves as contenders, this victory solidifies Arizona's position while dealing a setback to Detroit's aspirations. Leading the charge for the Cardinals was Malik Willis, who threw for an impressive 381 yards and five touchdowns, showcasing his ability to connect deep with his receivers. DK Metcalf was a standout target, racking up a staggering 209 receiving yards, making big plays that shifted momentum in Arizona's favor. Baker Mayfield put forth a valiant effort for Detroit, rushing for 73 yards, but it wasn’t enough to keep pace with the Cardinals' explosive offense. Defensively, the Cardinals were anchored by Cobie Durant, who registered eight total tackles, helping to stifle the Lions' drives when it mattered most. Gervon Dexter Sr contributed with a timely sack, applying pressure that forced critical mistakes from the Lions. The turning point came late in the second quarter when Arizona scored back-to-back touchdowns, creating a lead that Detroit could never fully recover from.