The San Francisco 49ers cruised to a decisive 37-6 victory over the Arizona Cardinals in Week 12 of the 2027 season, solidifying their playoff aspirations. With this win, the 49ers showcased their dominance and continued to establish themselves as a formidable force in the league. Bo Nix led the charge for San Francisco, throwing for 250 yards and two touchdowns, demonstrating both efficiency and poise in the pocket. RJ Harvey contributed significantly on the ground with 94 rushing yards, while Marvin Harrison Jr. made his mark as the top receiver, racking up 102 yards and providing a reliable target for Nix throughout the game. The 49ers' defense played a crucial role in the outcome, limiting the Cardinals to just six points and forcing them into multiple mistakes. Teair Tart was a standout, recording 1.5 sacks that disrupted Arizona's offensive rhythm, while Mike Jackson sealed the game with an interception. The turning point came early in the second half when San Francisco's defense stifled a potential scoring drive, allowing the 49ers to maintain control and pull away decisively.