In a high-stakes clash during Week 17 of the 2026 season, the San Francisco 49ers topped the Philadelphia Eagles with a final score of 45-28. Both teams were vying for playoff positioning, making this matchup crucial as the regular season comes to a close. The 49ers' explosive offense proved to be the difference-maker in a game filled with big plays. Jalen Hurts had a standout performance for the Eagles, throwing for an impressive 319 yards and three touchdowns, showcasing his ability to move the ball through the air despite the loss. DeVonta Smith led all receivers with 99 yards, providing a reliable target for Hurts. Meanwhile, Christian McCaffrey was the driving force for the 49ers on the ground with 92 rushing yards, contributing significantly to their offensive success. Defensively, the Eagles struggled to contain the 49ers' explosive playmakers. San Francisco's ability to create mismatches and exploit gaps in the Eagles' defense proved pivotal, especially when the 49ers scored two quick touchdowns in the third quarter to shift momentum. Although Jihaad Campbell registered a solid ten tackles for Philadelphia, it wasn't enough to turn the tide, ultimately allowing the 49ers to secure their victory and bolster their playoff hopes.