In a commanding performance, the Arizona Cardinals defeated the Los Angeles Rams 45-21 in Week 10 of the 2026 season. With playoff implications looming, the Cardinals showcased their dominance, solidifying their position in the divisional race. On the offensive side, Matthew Stafford led the Rams with 194 passing yards and three touchdown passes, but it was the Cardinals' Jeremiyah Love who stole the show with 97 rushing yards, helping to control the tempo of the game. Puka Nacua also stood out for the Rams, racking up 118 receiving yards, but it wasn’t enough to keep pace with the Cardinals’ balanced attack. The Cardinals' defense played a crucial role in the outcome, highlighted by Matt Milano's two sacks that disrupted Stafford's rhythm throughout the game. The turning point came in the second quarter when a critical interception from Trent McDuffie shifted the momentum, allowing the Cardinals to capitalize and extend their lead, ultimately sealing the victory.