In a tightly contested matchup, the Denver Broncos defeated the San Francisco 49ers 24-16 in Week 4 of the 2026 season. With both teams looking to establish momentum early in the season, the Broncos managed to hold off the 49ers' late-game push to secure the win. Baker Mayfield threw for an impressive 316 yards and one touchdown, showcasing his ability to lead the 49ers' offense. However, the standout on the ground was Jonathon Brooks, who contributed 68 rushing yards for the Broncos. Meanwhile, Elijah Arroyo was a key target for Mayfield, racking up 108 receiving yards and keeping the 49ers competitive throughout the game. Defensively, the Broncos made their presence felt with Anthony Hill Jr. leading the charge with 12 total tackles. The turning point came when Grant Delpit intercepted two passes, effectively stifling the 49ers' momentum at critical moments. James Pearce Jr. added a sack, further disrupting Mayfield's rhythm and helping the Broncos maintain their lead.