In a decisive Week 3 matchup, the San Francisco 49ers topped the Arizona Cardinals with a final score of 45-20, solidifying their dominance early in the 2026 season. The victory not only boosts the 49ers' confidence but also sends a clear message to the rest of the league about their offensive firepower. Quarterback Brock Purdy led the charge for San Francisco, throwing for an impressive 341 yards, while Christian McCaffrey contributed significantly on the ground with 94 rushing yards. For the Cardinals, Jacoby Brissett found the end zone twice through the air, but it was Michael Wilson's standout performance with 201 receiving yards that kept Arizona competitive in the contest. Defensively, Renardo Green was a standout for the 49ers, recording 11 tackles and an interception that turned the tide in favor of San Francisco. The pivotal moment came when Green's interception set up a quick touchdown drive, extending the 49ers' lead and effectively sealing the game. With such a strong defensive showing, San Francisco proved they can dominate on both sides of the ball.