In a commanding performance, the Indianapolis Colts defeated the Tennessee Titans 44-24 in Week 6 of the 2026 season. With playoff implications looming, the Colts showcased their dominance, putting the league on notice with this impressive victory. Quarterback Michael Penix Jr. led the charge for Indianapolis, throwing for three touchdowns and effectively managing the game. Kareem Hunt contributed significantly on the ground with 71 rushing yards, while Jayden Reed stood out as a receiving threat for the Titans, racking up 99 yards through the air. Jalen Hurts, despite the loss, demonstrated his ability with 277 passing yards for Tennessee. Defensively, the Colts made their mark with Alex Anzalone recording two sacks, disrupting Hurts' rhythm and contributing to key stops throughout the contest. The turning point came late in the second quarter when a timely interception set up a quick touchdown, allowing the Colts to widen their lead and control the pace of the game. The Titans struggled to recover from that momentum shift, ultimately falling short against a well-rounded Colts squad.