In a dominant performance, the Denver Broncos defeated the San Francisco 49ers 41-16 in Week 4 of the 2026 season. With both teams vying for momentum early in the season, the Broncos showcased their prowess, pulling away decisively to secure a convincing win. Quarterback Will Levis led the offensive charge for Denver, throwing for 312 yards and two touchdowns, effectively managing the game and exploiting the 49ers' defensive lapses. Aaron Jones Sr. contributed on the ground with 55 rushing yards, while the 49ers' KC Concepcion Jr. shined in defeat, racking up an impressive 153 receiving yards but unable to change the outcome. Defensively, the Broncos were relentless, highlighted by Josiah Trotter's standout performance with 11 total tackles and a crucial interception by Colton Hood that shifted momentum in the second half. The game's turning point came when Denver's defense stifled a late 49ers drive, allowing the Broncos to capitalize and extend their lead, ultimately sealing their commanding victory.