In a commanding display, the Los Angeles Rams triumphed over the San Francisco 49ers with a final score of 45-13 in Week 1 of the 2026 season. This victory sets the tone for the Rams as they aim to establish dominance in their division from the outset. Jared Goff led the charge for Los Angeles, throwing for an impressive 396 yards and five touchdowns, showcasing his sharp passing skills and ability to connect with his receivers. DJ Moore was a standout target, racking up 194 receiving yards, while Jaylen Warren contributed a solid ground game with 69 rushing yards, helping to keep the 49ers' defense on their heels throughout the contest. Defensively, the Rams were equally impressive, with Dre Greenlaw leading the team with nine tackles, keeping the 49ers' offensive plays in check. The game turned decisively in the Rams' favor midway through the second quarter when Goff connected for his third touchdown pass, widening the gap and forcing the 49ers into a desperate position. San Francisco struggled to recover from that momentum shift, allowing Los Angeles to cruise to a comfortable victory.