In a commanding performance, the New England Patriots triumphed over the Buffalo Bills with a final score of 66-21 in Week 4 of the 2026 season. This game showcased the Patriots' dominance, as they looked to solidify their standing in a competitive league while the Bills aimed to bounce back from recent struggles. Drake Maye led the charge for New England, throwing for four touchdowns and efficiently orchestrating the offense. TreVeyon Henderson was a force on the ground, rushing for an impressive 219 yards, while DJ Moore of the Bills stood out in the receiving game, racking up 287 yards despite the lopsided score. Will Levis also put up big numbers for Buffalo with 427 passing yards, but it wasn't enough to keep pace with the Patriots' explosive attack. Defensively, the Patriots were relentless, with Robert Spillane making a significant impact by recording three interceptions and six total tackles. This defensive prowess was critical in shifting the momentum, particularly when Spillane's pick-six turned the tide, firmly placing New England in control. Dorian Williams managed one sack for Buffalo, but the lack of consistent pressure allowed the Patriots to dominate both sides of the ball.