In a decisive Week 5 matchup, the Seattle Seahawks topped the San Francisco 49ers with a commanding 45-22 victory. This win solidifies the Seahawks' position in the playoff race as they look to build momentum heading into the second half of the season. Seattle's offensive showcase was led by quarterback Jalen Milroe, who threw for an impressive 397 yards and five touchdowns, demonstrating his ability to slice through the 49ers' secondary. Meanwhile, Jadarian Price contributed significantly on the ground with 105 rushing yards, and Jaxon Smith-Njigba was a standout receiver, racking up 196 yards, making the Seahawks' offense nearly unstoppable on the day. Defensively, the Seahawks made their mark with timely pressure and key turnovers that shifted the momentum. DeMarcus Lawrence recorded two sacks, disrupting the 49ers' rhythm, while Devon Witherspoon's interception helped to halt a potential scoring drive. The turning point came late in the second quarter when Seattle's defense stifled a 49ers drive, allowing the Seahawks to extend their lead and ultimately secure the victory.