In a thrilling Week 4 matchup, the Buffalo Bills held off the New England Patriots with a final score of 28-22. The stakes were high as both teams sought to solidify their positions in the competitive AFC East, but it was Buffalo that emerged victorious on their home turf. Jim Kelly was the standout performer for the Bills, throwing for 244 yards and four touchdowns, showcasing his elite playmaking ability. Meanwhile, Andre Reed was a key target, racking up an impressive 154 receiving yards, constantly challenging the Patriots’ secondary. For New England, Joe Mixon led the ground game with 76 rushing yards, but it wasn’t enough to overcome the Bills' offensive onslaught. Defensively, the Bills made critical plays that shifted the momentum in their favor. Carson Schwesinger led the charge with nine total tackles, while Brian Branch contributed with a key interception that thwarted a potential scoring drive for the Patriots. The turning point came late in the fourth quarter when Buffalo's defense held strong, allowing them to maintain their lead and secure the victory.