In a thrilling Week 18 showdown, the San Francisco 49ers topped the Arizona Cardinals with a final score of 38-27, securing a crucial victory as they head into the postseason. Both teams battled fiercely, but the 49ers' offensive firepower ultimately proved too much for the Cardinals to handle. Brock Purdy shined for San Francisco, tossing four touchdown passes while leading the team to a commanding offensive performance. Christian McCaffrey added a strong ground game with 114 rushing yards, and the duo of Deebo Samuel and George Kittle consistently found ways to exploit the Cardinals' secondary. On the other side, Sam Darnold threw for 349 yards and kept Arizona competitive, but it wasn’t enough to overcome the 49ers' offensive output. Defensively, the 49ers made significant contributions, with Nick Bosa dominating the line with 3.5 sacks, creating pressure that disrupted Arizona's rhythm. The turning point came in the second half when Malik Mustapha intercepted a pass, halting a promising Cardinals drive and allowing the 49ers to extend their lead. Dre Greenlaw led the tackling efforts with four total tackles, anchoring a defense that played a pivotal role in San Francisco's victory.