The San Francisco 49ers outlasted the Arizona Cardinals with a final score of 45-28 in a pivotal Week 3 matchup of the 2026 season. This victory not only boosts San Francisco's record but also establishes them as a formidable contender early in the season. Brock Purdy led the charge for the 49ers, throwing for 312 yards and four touchdowns, showcasing his ability to command the offense. George Kittle was a standout target, racking up 111 receiving yards and consistently finding ways to exploit the Cardinals' secondary. On the ground, Jeremiyah Love kept Arizona competitive with a strong performance, rushing for 95 yards, but it wasn't enough to match San Francisco's offensive firepower. Defensively, the 49ers made their mark, with Mykel Williams dominating the pass rush and recording three sacks. Dre Greenlaw was a game-changer in the secondary, snagging three interceptions that shifted the momentum firmly in favor of San Francisco. The turning point came in the second quarter when Greenlaw's first pick set up Purdy's third touchdown pass, giving the 49ers a lead they would not relinquish.