In a thrilling Week 3 matchup, the Arizona Cardinals held off the San Francisco 49ers with a final score of 25-22, securing a crucial victory in the early 2028 season. The win marks an important milestone for the Cardinals as they look to establish their dominance in the NFC West. Sam Darnold showcased his prowess under center, throwing for a remarkable 305 yards, while Michael Wilson emerged as his favorite target, racking up 113 receiving yards. Despite the 49ers' Bryce Underwood throwing three touchdown passes, it wasn't enough to overcome the Cardinals' offensive firepower, as they consistently moved the chains and kept the pressure on San Francisco's defense. On the defensive side, DeMarvion Overshown led the charge for Arizona with 10 total tackles, demonstrating his ability to stifle the 49ers' rushing attack. The turning point of the game came late in the fourth quarter when Josh Sweat sacked Underwood, forcing a pivotal turnover that shifted momentum back to the Cardinals. With Fred Warner snagging an interception for the 49ers, it was clear that both defenses had their moments, but Arizona's unit stepped up when it mattered most.